Topology optimization of bone using cubic material design and evolutionary methods based on internal remodeling

I.Goda, J.-F. Ganghoffer, S.Czarnecki, R.Czubacki, P.Wawruch, Topology optimization of bone using cubic material design and evolutionary methods based on internal remodeling,  Mechanics Research Communications, 95(2019), pp. 52-60 on-line>> Highlights • Optimal bone tissue mechanical properties and anisotropy directions are computed based on Cubic Material Design for the minimum compliance optimization problem considering cubic symmetry. • The evolution in time of internal bone density and anisotropic properties are computed based on evolutionary algorithms relying on internal remodeling simulations. • Simulation results indicate that the proposed approaches reasonably mimic the major geometrical and material features of natural bone.